Endoform® Platform

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Endoform® is a high performance building block for developing a wide range of regenerative tissue substitutes to assist with tissue repair and healing.

 

Endoform® is a proprietary extracellular matrix (ECM) biomaterial containing a rich and complex mix of important biological molecules, including structural (collagens I, III, IV & elastin) and adhesive proteins (fibronectin and laminin), glycosaminoglycans (heparin sulphate and hyaluronic acid) and growth factors (FGF2 & TGFß).

Endoform_platform

Cells and the surrounding ECM constantly interact to modulate tissue physiology. ECM components play important roles in regulating tissue growth and maintenance and orchestrating the process of tissue regeneration. The delicate micro-architecture influences the way cells attach, migrate, grow and differentiate. Structural proteins such a collagens and elastin support cells as well as binding and releasing growth factors, cytokines, peptide fragments, proteoglycans and glycosaminoglycans. Collagen and elastin also act as substrates for matrix metalloproteinases (MMP’s) and elastase.

Importantly, as a cell-free native extracellular matrix, Endoform retains authentic structure, signals and substrates providing a uniquely supportive environment to guide the growth of cells and new tissue.

Endoform demonstrates quantitatively superior vascularization, rapid cell infiltration and improved modulation of matrix metalloproteinase activity compared with current market leaders in a range of preclinical studies and this is known to influence the rate and quality of tissue repair.

Endoform is a building block that can serve as the underlying architecture for a wide range of medical devices. Our proprietary fabrication technology provides flexibility to develop constructs with profiles and performance to suit a wide range of anatomical sites. It can also be combined with complementary polymer, signalling and cell technologies to achieve specific functional requirements.

Endoform is derived from ovine forestomach and includes a unique combination of basement membrane remnants and propria-submucosa. Its unique structure results in a dense contoured matrix on one side and an open smooth matrix on the other. It is conforming, robust, and has high tensile strength. By careful control of the manufacturing process we retain the propria-submucosa’s innate biological structure and composition. Additionally, the ovine source combined with New Zealand’s disease-free status and our proprietary purification and sterilization processes aim to ensure the highest level of safety.

When applied or implanted clinically, Endoform immediately provides a supportive function. It allows the attachment, migration and growth of mesenchymal cells and, in time, is replaced by new tissue to provide a functional tissue analogue. It is well tolerated and does not elicit a significant immune response.

Compared to alternative ECM offerings Endoform provides:

  • Authentic structure, signals and substrates of a minimally processed native extracellular matrix
  • Superior blood vessel in-growth based on pre-clinical in-vitro and in-vivo studies
  • Complete remodelling and replacement over time
  • Excellent strength and handling characteristics
  • A flexible and tenable biomaterial platform for the development of a wide range of tissue healing and repair devices

 

Technical Literature

Lun, S., et al., A functional extracellular matrix biomaterial derived from ovine forestomach. Biomaterials, 2010. 31(16): p. 4517-29.

Floden, E.W., et al., Biophysical characterization of ovine forestomach extracellular matrix biomaterials. J Biomed Mater Res B Appl Biomater, 2010. 96(1): p. 67-75.

Irvine, S.M., et al., Quantification of in vitro and in vivo angiogenesis stimulated by ovine forestomach matrix biomaterial. Biomaterials, 2011. 32(27): p. 6351-61.

Negron, L., S. Lun, and B.C.H. May, Ovine forestomach matrix biomaterial is a broad spectrum inhibitor of matrix metalloproteinases and neutrophil elastase. Int Wound J, 2014. 11(4): p. 392-397.

Sizeland, K.H., et al., Collagen Fibril Response to Strain in Scaffolds from Ovine Forestomach for Tissue Engineering. ACS Biomater. Sci. Eng., 2017. 3(10): p. 2550–2558.

Street, M., et al., Augmentation with an ovine forestomach matrix scaffold improves histological outcomes of rotator cuff repair in a rat model. J Orthop Surg Res, 2015. 10: p. 165.

Tati, R., S. Nordin, and S.M. Abdillahi, Biological wound matrices with native dermis-like collagen efficiently modulate protease activity. Journal of Wound Care, 2018. 27(4): p. 199-209.

Merrilees, M.J., et al., Use of versican variant V3 and versican antisense expression to engineer cultured human skin containing increased content of insoluble elastin. J Tissue Eng Regen Med, 2014.

Endoform® is a leading tissue scaffold platform for developing a wide range of new tissue repair and healing products. For all enquiries relating to new product development please contact us.