Evidence

Peer-Reviewed Clinical Studies | Clinical Consensus Papers | Conference Proceedings | Peer-Reviewed Pre-Clinical Studies

 

Peer-Reviewed Clinical Studies

 

Ferreras, D. T., S. Craig and R. Malcomb (2017). “Use of an Ovine Collagen Dressing with Intact Extracellular Matrix to Improve Wound Closure Times and Reduce Expenditures in a US Military Veteran Hospital Outpatient Wound Center.” Surg Technol Int 30: 61-69. |full-text available|

Lullove, E. J. (2017). “Use of Ovine-based Collagen Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foam Dressings to Help Improve Clinical Outcomes in Lower Extremity Wounds: A Retrospective Cohort Study.” Wounds 29(4): 107-114. |full-text available|

Gonzalez, A. (2016). “Use of Collagen Extracellular Matrix Dressing for the Treatment of a Recurrent Venous Ulcer in a 52-Year-Old Patient.” J Wound Ostomy Continence Nurs 43(3): 310-312. |abstract only|

Bohn, G. A. and K. Gass (2014). “Leg ulcer treatment outcomes with new ovine collagen extracellular matrix dressing: a retrospective case series.” Adv Skin Wound Care 27(10): 448-454. |abstract only|

Liden, B. A. and B. C. May (2013). “Clinical outcomes following the use of ovine forestomach matrix (endoform dermal template) to treat chronic wounds.” Adv Skin Wound Care 26. |abstract only|

Simcock, J. and B. C. May (2013). “Ovine forestomach matrix as a substrate for single-stage split-thickness graft reconstruction.” Eplasty 13: e58.|full-text available|

Simcock, J. W., M. Than, B. R. Ward and B. C. May (2013). “Treatment of ulcerated necrobiosis lipoidica with ovine forestomach matrix.” J Wound Care 22(7): 383-384. |abstract only|

 

 

Clinical Consensus Papers

 

Bohn, G. A. (2019). “Endoform: A Simple Tool to Assess Wound Proteases.” Wound Management and Prevention 65(3): 18-20. |abstract only|

Edwards, K. (2018). “Collaborating with WOC Nurses to Optimize Patient Progress.” Ostomy and Wound Management May 2018: 10-12. |abstract only|

Gonzalez, A. (2018). “Managing Pressure Injuries in Home Health Care.” Ostomy and Wound Management 64(4): 12-14. |abstract only|

Zilberman, I. and N. Zolfaghari (2018). “Taking the Guess Work Out of Silver Use.” Ostomy and Wound Management October 2018: 12-14. |abstract only|

Zilberman, I. and N. Zolfaghari (2018). “Adding an Antimicrobial With Silver to Your Wound Care Armamentarium.” Ostomy and Wound Management August 2018: 10-11. |abstract only|

Bohn, G. A., G. S. Schultz, B. A. Liden, M. N. Desvigne, E. J. Lullove, I. Zilberman, M. B. Regan, M. Ostler, K. Edwards, G. M. Arvanitis and J. F. Hartman (2017). “Proactive and Early Aggressive Wound Management: A Shift in Strategy Developed by a Consensus Panel Examining the Current Science, Prevention, and Management of Acute and Chronic Wounds.” Wounds 29(11): S37-S42. |full-text available|

Ferreras, D. T. (2017). “Wound Bed Preparation: Is It Time to Up Your Game?” Ostomy and Wound Management 63(12): 10-11. |abstract only|

Bohn, G., B. Liden, G. Schultz, Q. Yang and D. J. Gibson (2016). “Ovine-Based Collagen Matrix Dressing: Next-Generation Collagen Dressing for Wound Care.” Adv Wound Care (New Rochelle) 5(1): 1-10. |full-text available|

Sibbald, R. G., L. G. Ovington, E. A. Ayello, L. Goodman and J. A. Elliott (2014). “Wound bed preparation 2014 update: management of critical colonization with a gentian violet and methylene blue absorbent antibacterial dressing and elevated levels of matrix metalloproteases with an ovine collagen extracellular matrix dressing.” Adv Skin Wound Care 27(3 Suppl 1): 1-6. |abstract only|

 

 

Conference Proceedings

|full-text available|

 

2019

Hill, R., R. Raizman and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. NSWOCC 38th National Conference, Lac-Leamy, Ottawa, Canada.

Raizman, R., R. Hill and K. Woo (2019). Multi-Center Evaluation of an Advanced Extracellular Matrix Technology for the Management of Chronic Wounds – A Canadian Experience. Wounds Canada – Spring, Halifax, NS, Canada.

Casilang, R., E. Hicks and S. Morrisette (2019). Early Clinical Experience Using an ECM Scaffold with Ionic Silver in Diabetic Patients with Lower Extremity Ulcers. 41st Annual Boswick Burn & Wound Symposium, Wailea Beach, Maui, HI.

 

2018

Aballay, A. and E. Tolchin (2018). Results of an ovine extracellular matrix dressing in the management of a variety of burns and wounds. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

Fleck, K. A., T. Reyes and H. C. Wishall (2018). Effect of Ovine-Based Collagen Extracellular Matrix Dressings on Outcomes in an Outpatient Wound Care Center. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

Jerome, D. and J. Clancy (2018). Incorporating advanced wound care to help restore skin health in three patients with peristomal skin complications. Wound Ostomy and Continence Nurse Conference, St. Louis,  MO.

Lindberg, G. and M. Diss (2018). Complete Wound Closure in Partial Thickness Burns with the Use of Collagen Extracellular Matrix Dressings and Antibacterial Foams. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

Mier, Y. (2018). Case Series of using collagen dressing in stalled wounds. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

Gatan Mendoza, J., J. Landi and R. Rock (2018). The concurrent Use of Ovine Collagen Extracellular Matrix Dressing with Negatvie Pressure Wound Therapy on Three Acute Surgical Wounds. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

Tickner, A., C. Klinghard and K. Lussier (2018). The Use of Ovine Collagen Extracellular Matrix Dressing in the Effective Treatment of Wounds for Fast Closure and Treatment of Nerve Pain. Symposium on Advanced Wound Care – Spring, Charlotte, NC.

Andersen, C., D. Green, J. Santucci and E. Phillips (2018). Improved Venous Leg Ulcer Outcomes Using a Combination of Ovine Extracellular Matrix and Gentian Violet/Methylene Blue Transfer Antibacterial Foam. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

Morrisette, S., E. Hicks and R. Casilang (2018). Achieving Improved Wound Healing Time and Costs Savings in the Outpatient Wound Care Setting by Utilizing an Extracellular Matrix. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

Silverman, A. and G. Valentine (2018). Use of Ovine Extracellular Matrix in Post-Surgical Wounds: A Case Series. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

Stillerman, J. (2018). Case Series Using Ovine Extracellular Matrix for the Correction of Stalled Wounds Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

Casilang, R., E. Hicks and S. Morrisette (2018). Early Clinical Experience Using an ECM Scaffold with Ionic Silver in Diabetic Patients with Lower Extremity Ulcers. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

Stillerman, J. (2018). To Preserve and Protect: a Dual Approach to Wound Management using an Extracellular Matrix with Ionic Silver Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

Zilberman, I. and N. Zolfaghari (2018). Innovative Solutions Utilizing Ovine Extracellular Matrix with Antimicrobial Silver in the Management of Wounds with Exposed Tendon and Bone. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

 

2017

McIlrath, P. and J. T. Wattlers (2017). The Use of Ovine Collagen Extracellular Matrix and Gentian Violet and Methylene Blue Antibacterial Foam Dressings in the Effective Treatment of Wounds with Exposed Tendon and Bone in the High Risk Diabetic Foot. Society for Advanced Wound Care – Spring, San Diego, CA.

Silverman, A. (2017). Use of an Ovine Collagen with an Intact Extracellular Matrix (CECM) and negative pressure wound therapy (NPWT) as part of the wound management plan following limb salvage surgical intervention in high risk diabetic foot ulcers. Symposium on Advanced Wound Care – Spring, San Diego, CA.

 

2016

Bohn, G. and S. Champion (2016). Improved Healing of Stage 3 Pressure Ulcers Using Extracellular Matrix Collagen Dressing. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Desvigne, M. N. (2016). Preparing a wound bed before application of cellular tissue based products using an Ovine collagen (CECM) dressing with an intact extracellular matrix. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Edwards, K., White S. (2016). Use of gentian violet and methylene blue antibacterial foam dressings on various wound types in the acute care setting. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Ferreras, D. T., S. Craig and R. Malcomb (2016). Utilization of an ovine collagen dressing with an intact extracellular matrix (CECM) within a dual-protocol algorithm to improve wound closure times and reduce expenditures in a VA Hospital. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Gonzalez, A. (2016). Use of Collagen Extracellular Matrix Dressing for the Treatment of a Recurrent Venous Ulcer in a 52-Year-Old Patient. Symposium on Advanced Wound Care – Spring, Atlanta, GA.

Petrocelli, M. Ostler, M. Liden, B. (2016). Edema reduction with a Novel Total Contact Cast System containing a Mild Compression Sock. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Petrocelli, M. (2016). Managing Difficult Wounds Secondary to Charcot Deformity with a Novel Total Contact Cast System. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Roith, J. (2016). Managing Diabetic Foot Ulcers Using a Three Pronged Approach: V.I.P. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.

Vidovic, G. and P. Sykes (2016). The use of an ovine collagen extracellular matrix dressing in conjunction with negative pressure wound therapy in the management of chronic diabetic foot ulcers. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Zilberman, I. and N. Zolfaghari (2016). Innovative solutions in the management of wounds with exposed tendons utilizing ovine collagen extracellular matrix and gentian violet and methylene blue antibacterial foams. Symposium for Advanced Wound Care – Spring, Atlanta, GA.

 

2015

Champion, S. and G. Bohn (2015). Dressing Appearance at Change Can Give Insight into Dressing Effectiveness in the Wound. Symposium on Advances in Skin & Wound Care – Spring, New Orleans, LA.

Desvigne, M. N. (2015). Ovine collagen extracellular matrix (CECM) Dressing Assisted Closure: For the Acute Wound, Following Mohs Surgical Excision. Clinical Symposium on Advances in Skin & Wound Care. New Orleans, LA.

McGuire, J., N. Mahmudova and W. Lee (2015). Using becaplermin and ovine dermal template (ODT) dressing to heal chronic diabetic foot ulcers. A case series. American Podiatric Medical Association 2015 Annual Scientific Meeting (The National), Orlando, FL

Pierce, B., J. Galitz, L. Hayes and M. Regan (2015). Wound Management and Estimated Cost Associated with Dermal Templates Containing 10% Extracellular Matrix Components and 90% Intact Collagen. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Roith, J. and T. Neill (2015). Treating Diabetic Foot Ulcer Patients with an Ovine Collagen Extra Cellular Matrix Prior to cellular Tissue Products. Annual High Risk Diabetic Foot Conference, Phoenix, AZ.

Weir, D., D. Tedesco and G. Schultz (2015). Enhanced Clinical Effects of Combining Recombinant PDGF with Collagen Dressings in Difficult to Heal Chronic Wounds. Symposium for Advanced Wound Care –  Spring, New Orleans, LA.

 

2014

Blaszcyk, J. and A. McIntosh (2014). The effectiveness of an ovine collagen extracellular matrix dressing for chronic non-healing wounds. Symposium on Advanced Wound Care – Spring, Denver, CO.

Lullove (2014). Pilot series of recalcitrant lower extremity wounds managed with an ovine collagen extracellular matrix (CECM) and gentian violet/methylene blue (GV/MB) antibacterial foam dressings. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Zilberman, I. and N. Zolfaghari (2014). Use of ovine collagen extracellular matrix (CECM) dressing and gentian violet and methylene blue (GV/MB) antimicrobial foam dressing in the management of diabetic foot ulcers. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

 

2013

Curran, M., C. Rodriquez, O. J. Altschul, A. Fragen and F. Ercoll (2013). The Use of collagen dermal template with an ECM in various wounds in acute care and outpatient wound care settings. Symposium on Advanced Wound Care – Spring, Denver, CO

Lullove, E. (2013). Use of a collagen dermal template with extracellular matrix (ECM) to treat complex lower extremity wounds. Clinical Symposium on Advances in Skin & Wound Care, Orlando, FL.

Miller, S. D., K. Trotter, B. Hong, R. Lenz, D. Nagesh, H. K. Park and M. Garoufalis (2013). An Approach to Treating Neuropathic Pedal Ulcerations with Ovine Collagen Extracellular Matrix (CECM). Symposium on Advanced Wound Care – Spring, Denver, CO.

Pompeo, M., K. Neeley and L. Garner (2013). Utilizing a collagen dermal template in various wound etiologies yielded positive results in an outpatient wound care center. Symposium on Advanced Wound Care – Spring, Denver, CO.

Wright, K., D. Hastings, W. Dukes and K. Gorgui (2013). Innovative Dressing Option: Use of a collagen dermal template with extracellular matrix (ECM)* in the management of lower extremity wounds. Clinical Symposium on Advances in Skin & Wound Care, Orlando, FL.

 

2012

 

2011

Liden, B., B. R. Ward and B. C. H. May (2011). Early Clinical Findings from the Use of Ovine Forestomach Matrix to Treat Recalcirant Wounds. Symposium on Advanced Wound Care – Spring, Dallas, Tx.

 

 

Peer-Reviewed Pre-Clinical Studies

 

Dempsey, S. G., C. H. Miller, R. C. Hill, K. C. Hansen and B. C. H. May (2019). “Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix.” J Proteome Res 18(4): 1657-1668.|full-text available|

Karnik, T., S. G. Dempsey, M. J. Jerram, A. Nagarajan, R. Rajam, B. C. H. May and C. H. Miller (2019). “Ionic silver functionalized ovine forestomach matrix – a non-cytotoxic antimicrobial biomaterial for tissue regeneration applications.” Biomater Res 23: 6. |full-text available|

Sizeland, K. H., H. C. Wells, S. J. R. Kelly, K. E. Nesdale, B. C. H. May, S. G. Dempsey, C. H. Miller, N. Kirby, A. Hawley, S. Mudie, T. Ryan, D. Cookson and R. G. Haverkamp (2017). “Collagen Fibril Response to Strain in Scaffolds from Ovine Forestomach for Tissue Engineering.” ACS Biomater. Sci. Eng. 3(10): 2550–2558. |abstract only|

Street, M., A. Thambyah, M. Dray, S. Amirapu, D. Tuari, K. E. Callon, J. D. McIntosh, K. Burkert, P. R. Dunbar, B. Coleman, J. Cornish and D. S. Musson (2015). “Augmentation with an ovine forestomach matrix scaffold improves histological outcomes of rotator cuff repair in a rat model.” J Orthop Surg Res 10: 165. |abstract only|

Negron, L., S. Lun and B. C. H. May (2014). “Ovine forestomach matrix biomaterial is a broad spectrum inhibitor of matrix metalloproteinases and neutrophil elastase.” Int Wound J 11(4): 392-397. |abstract only|

Irvine, S. M., J. Cayzer, E. M. Todd, S. Lun, E. W. Floden, L. Negron, J. N. Fisher, S. G. Dempsey, A. Alexander, M. C. Hill, A. O’Rouke, S. P. Cunningham, C. Knight, P. F. Davis, B. R. Ward and B. C. H. May (2011). “Quantification of in vitro and in vivo angiogenesis stimulated by ovine forestomach matrix biomaterial.” Biomaterials 32(27): 6351-6361. |abstract only|

Floden, E. W., S. F. Malak, M. M. Basil-Jones, L. Negron, J. N. Fisher, S. Lun, S. G. Dempsey, R. G. Haverkamp, B. R. Ward and B. C. May (2010). “Biophysical characterization of ovine forestomach extracellular matrix biomaterials.” J Biomed Mater Res B Appl Biomater 96(1): 67-75. |abstract only|

Lun, S., S. M. Irvine, K. D. Johnson, N. J. Fisher, E. W. Floden, L. Negron, S. G. Dempsey, R. J. McLaughlin, M. Vasudevamurthy, B. R. Ward and B. C. H. May (2010). “A functional extracellular matrix biomaterial derived from ovine forestomach.” Biomaterials 31(16): 4517-4529. |abstract only|