Endoform® Antimicrobial

Endoform® Antimicrobial Is an extracellular matrix which supports all phases of healing. It contains:

Natural intact collagen scaffold
Secondary molecules that are important during healing
Only natural tissue components

Endoform® Antimicrobial is a natural collagen scaffold with 0.3% ionic silver to protect it from microbial colonisation. Benefits include:

Minimal impact on cell viability
Provides extended antimicrobial protection for up to 7 days
Has a wide spectrum of antimicrobial protection

Products

Endoform® Antimicrobial Dermal Template is an advanced wound care dressing primarily composed of natural, non-reconstituted collagen retaining the native extracellular matrix associated macromolecules including fibronectin, glycosaminoglycans, laminin, and elastin.

Endoform® Antimicrobial Dermal Template contains approximately 12 pg/cm2 (-0.3% w/w) ionic silver, intended to inhibit colonisation of the dressing. The dressing is effective against a broad spectrum of microbes, including Acinetobacter baumannii, Candida albicans, Candida parapsilosis, Candida glabrata, Escherichia coli, Methicillin Resistant Staphylococcus aureus (MRSA), coagulase negative Staphylococci, group A (beta-hemolytic) Streptococci, Pseudomonas aeruginosa, Aspergillus niger; and Vancomycin Resistant Enterococci (VRE). The dressing provides sustained antimicrobial effectiveness within the dressing for up to 7 days.

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Endoform Antimicrobial Dermal Template is indicated for the management of wounds including:

Partial and full thickness wounds
Pressure ulcers
Venous ulcers
Diabetic ulcers
Chronic vascular ulcers
Tunneled/undermined wounds
Surgical wounds (donor sites, grafts, post Moh’s surgery, post laser surgery, podiatric, wound dehiscence)
Traumatic wounds (abrasions, lacerations, first and second degree burns, and skin tears)
Draining wounds

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The performance of Endoform® Antimicrobial is supported by clinical evidence.

Peer-Reviewed Clinical Studies | Clinical Consensus Papers | Conference Proceedings | Peer-Reviewed Pre-Clinical Studies

Peer-reviewed Clinical Studies

Clinical Consensus Papers

Zilberman, I. and N. Zolfaghari (2018). “Taking the Guess Work Out of Silver Use.” Ostomy and Wound Management October 2018: 12-14. |abstract only|

Zilberman, I. and N. Zolfaghari (2018). “Adding an Antimicrobial With Silver to Your Wound Care Armamentarium.” Ostomy and Wound Management August 2018: 10-11. |abstract only|

Conference Proceedings

|full-text available|

2020

Hill, R. and K. Woo (2020). Utilization of advanced antimicrobial extracellular matrix technology within the framework of antimicrobial stewardship. Symposium on Advanced Wound Care – Spring 2020 Virtual.

Melin, M. and C. Zeleya (2020). Chronic wound management with the innovative ovine extracellular matrix technology: a Honduran experience. Symposium on Advanced Wound Care – Spring 2020 Virtual.

2019

Zilberman, I. and N. Zolfaghari (2019). The management of wounds with exposed tendon and bone with innovative and complementary technologies: ovine extracellular matrix and gentian violet/methylene blue antibacterial foams. Symposium on Advanced Wound Care – Fall, Las Vegas, NV.

Morrisette, S., R. Casilang and G. Bohn (2019). Extracellular Matrix Technology for Assessing Wound Protease Concentrations Symposium of Advanced Wound Care – Spring, San Antonio, Tx.

Zilberman, I. and N. Zolfaghari (2019). The Management of Wounds with Exposed Tendon and Bone using Innovative and Complementary Technologies: Ovine Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foams. Symposium on Advanced Wound Care – Spring, San Antonio, TX.

Stillerman, J. and D. M. Freeman (2019). Using Advanced and Adaptive Technologies for the Management of Wounds – Extracellular Matrix and Gentian Violet/Methylene Blue Antibacterial Foam Dressing. Symposium for Advanced Wound Care – Spring, San Antonio, TX.

Casilang, R., E. Hicks and S. Morrisette (2019). Early Clinical Experience Using an ECM Scaffold with Ionic Silver in Diabetic Patients with Lower Extremity Ulcers. 41st Annual Boswick Burn & Wound Symposium, Wailea Beach, Maui, HI.

Peer-Reviewed Pre-Clinical Studies

Dempsey, S. G., C. H. Miller, J. Schueler, R. W. F. Veale, D. J. Day and B. C. H. May (2020). “A novel chemotactic factor derived from the extracellular matrix protein decorin recruits mesenchymal stromal cells in vitro and in vivo.” PLoS One 15(7): e0235784 |full-text available|

Overbeck, N., G. M. Nagvajara, S. Ferzoco, B. C. H. May, A. Beierschmitt and S. Qi (2020). “In-vivo evaluation of a reinforced ovine biologic: a comparative study to available hernia mesh repair materials.” Hernia |full-text available|

Frost, S. J., D. Mawad, R. Wuhrer, S. Myers and A. Lauto (2018). “Semitransparent bandages based on chitosan and extracellular matrix for photochemical tissue bonding.” Biomed Eng Online 17(1): 7. |full-text available|

Dempsey, S. G., C. H. Miller, R. C. Hill, K. C. Hansen and B. C. H. May (2019). “Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix.” J Proteome Res 18(4): 1657-1668.|full-text available|

Karnik, T., S. G. Dempsey, M. J. Jerram, A. Nagarajan, R. Rajam, B. C. H. May and C. H. Miller (2019). “Ionic silver functionalized ovine forestomach matrix – a non-cytotoxic antimicrobial biomaterial for tissue regeneration applications.” Biomater Res 23: 6. |full-text available|

Dempsey, S. G., S. Cutajar, A. Nagarajan, R. Rajam, M. J. Jerram, T. Karnik, C. H. Miller and B. C. H. May (2018). Structural Diversity of Decellularized Ovine Forestomach Matrix. Symposium on Advanced Wound Care – Fall, Las Vegas, NV. |full-text available|

Karnik, T., M. J. Jerram, A. Nagarajan, R. Rajam, S. G. Dempsey, B. C. May and C. H. Miller (2018). Antimicrobial Functionalization of Ovine Forestomach Matrix With Ionic Silver. Symposium on Advanced Wound Care – Spring, Charlotte, NC. |full-text available|

Jerram, M. J., T. Karnik, A. Nagarajan, R. Rajam, S. G. Dempsey, B. C. May and C. H. Miller (2018). Antimicrobial Ovine Forestomach Matrix Prevents Biofilm Formation. Symposium on Advanced Wound Care – Spring, Charlotte, NC. |full-text available|

Sizeland, K. H., H. C. Wells, S. J. R. Kelly, K. E. Nesdale, B. C. H. May, S. G. Dempsey, C. H. Miller, N. Kirby, A. Hawley, S. Mudie, T. Ryan, D. Cookson and R. G. Haverkamp (2017). “Collagen Fibril Response to Strain in Scaffolds from Ovine Forestomach for Tissue Engineering.” ACS Biomater. Sci. Eng. 3(10): 2550–2558. |abstract only|

Street, M., A. Thambyah, M. Dray, S. Amirapu, D. Tuari, K. E. Callon, J. D. McIntosh, K. Burkert, P. R. Dunbar, B. Coleman, J. Cornish and D. S. Musson (2015). “Augmentation with an ovine forestomach matrix scaffold improves histological outcomes of rotator cuff repair in a rat model.” J Orthop Surg Res 10: 165. |abstract only|

Negron, L., S. Lun and B. C. H. May (2014). “Ovine forestomach matrix biomaterial is a broad spectrum inhibitor of matrix metalloproteinases and neutrophil elastase.” Int Wound J 11(4): 392-397. |abstract only|

Irvine, S. M., J. Cayzer, E. M. Todd, S. Lun, E. W. Floden, L. Negron, J. N. Fisher, S. G. Dempsey, A. Alexander, M. C. Hill, A. O’Rouke, S. P. Cunningham, C. Knight, P. F. Davis, B. R. Ward and B. C. H. May (2011). “Quantification of in vitro and in vivo angiogenesis stimulated by ovine forestomach matrix biomaterial.” Biomaterials 32(27): 6351-6361. |abstract only|

Irvine, S. M., J. Cayzer, E. M. Todd, S. Lun, E. W. Floden, L. Negron, S. G. Dempsey, A. Alexander, S. P. Gunningham, C. Knight, P. F. Davis, B. R. Ward and B. C. H. May (2011). Ovine Forestomach Matrix (OFM) Stimulates Angiogenesis In Vitro and In Vivo. Symposium on Advanced Wound Care – Spring, Dallas, TX. |full-text available|

Floden, E. W., S. F. F. Malak, M. M. Basil-Jones, L. Negron, J. N. Fisher, S. Lun, S. G. Dempsey, R. G. Haverkamp, B. R. Ward and B. C. H. May (2011). Biophysical Characterisation of Ovine Forestomach Extracellular Matrix Biomaterials. Australasian Society for Biomaterials and Tissue Engineering, Queenstown, New Zealand. |full-text available|

Floden, E. W., S. F. Malak, M. M. Basil-Jones, L. Negron, J. N. Fisher, S. Lun, S. G. Dempsey, R. G. Haverkamp, B. R. Ward and B. C. May (2010). “Biophysical characterization of ovine forestomach extracellular matrix biomaterials.” J Biomed Mater Res B Appl Biomater 96(1): 67-75. |abstract only|

Lun, S., S. M. Irvine, K. D. Johnson, N. J. Fisher, E. W. Floden, L. Negron, S. G. Dempsey, R. J. McLaughlin, M. Vasudevamurthy, B. R. Ward and B. C. H. May (2010). “A functional extracellular matrix biomaterial derived from ovine forestomach.” Biomaterials 31(16): 4517-4529. |abstract only|

May, B. C. H., S. M. Irvine, S. Lun, E. W. Floden and B. R. Ward (2010). Ovine Forestomach Matrix (EndoformTM) Stimulates Cell Differentiation and Vascularisation. Symposium on Advanced Wound Care – Spring, Orlando, FL. |full-text available|

May, B. C. H., S. Lun, J. N. Fisher, E. W. Floden and B. R. Ward (2009). Endoform(TM) Dermal Template – Authentic Complexity. Symposium on Advanced Wound Care – Spring, Dallas, Tx. |full-text available|

Products

Instructions for Use

Brochure

Application Guide

Materials Safety Data Sheet

Video Resource Library | Clinical Resource Library

Canadian Resource Library | Patient Resource Library

Video Resource Library

How to apply Endoform® Natural and Endoform® Antimicrobial

Endoform® Mechanism of Action – Protease Modulation

Endoform® extracellular matrix (ECM) stays intact in the wound bed to help provide visual cues to wound healing and modulate unbalanced wound proteases. This animation describes how Endoform® works in the wound bed to assist with wound healing and help build new tissue.

Endoform® Application in Pediatrics

Watch as Dr. Amaya (Pediatric Wound Care & Laser Specialists, Houston, Texas) demonstrates the proper use of Endoform® to dress and protect a child’s wounds. This dermal template helps wounds heal and close, as well as help grow new skin over your child’s wound.

Clinical Resource Library

NEW RESOURCE – Using Endoform® to Escape the Inflammatory Phase Earlier

Chronic wounds are characterized by elevated wound proteases and high bioburden which limits healing and traps wounds in the inflammatory phase. The following Clinical Resource shows how Endoform® can be used to help wounds escape the inflammatory phase.