Natural structure and engineered architecture enables rapid cell access.
Myriad™ retains the authentic structure and complexity of natural tissue ECM and provides biological cues to aid the repair process. Myriad™ contains 151 ECM proteins, including collagen and other secondary molecules that exist in tissue and aid the healing process [1,2,3,4]
Angioconduction is the structural effect of vascular channels on endothelial cells to support blood vessel development . Studies have shown that when present in a graft material, natural vascular channels lead to a denser and more rapidly forming capillary network . Myriad™ contains an extensive network of vascular channels within the natural ECM . The vascular channels provide immediate and specific vascular architecture to support migrating endothelial cells to establish new vasculature and a robust blood supply [2,5].
Representative image of residual vascular channels present in Myriad™ ECM following dye perfusion (left) . Vasularization of the ECM in vivo (right) .
Myriad™ is designed to be easy to customize for a wide range of anatomical sites and individual situations. It is strong, soft, drapable, and conforming. It rehydrates quickly, and is easy to handle, cut, suture or staple. Myriad™ helps to achieve surgical mastery in routine and more challenging repair and reinforcement procedures.
Endoform® ECM technology has been in clinical use for over 10 years and over 5 million devices have been used in a range of soft tissue repair procedures, including wounds, abdominal wall repair, plastics and reconstructive surgery. Endoform® is a leading ECM technology for soft tissue repair.
Myriad™ is indicated for both implant and dermal procedures. Myriad™ is designed for use by a range of surgical specialties, including plastics, general, vascular and podiatric surgeons.
Myriad™ is suitable for a wide range of plastic and reconstructive surgical procedures where soft tissue requires repair or reinforcement. The structure and biology of Myriad™ may also help healing in patients with impaired or compromised healing due to local or systemic factors.
1. Lun, S., et al., A functional extracellular matrix biomaterial derived from ovine forestomach. Biomaterials, 2010. 31(16): p. 4517-29. 2. Irvine, S.M., et al., Quantification of in vitro and in vivo. angiogenesis stimulated by ovine forestomach matrix biomaterial. Biomaterials, 2011. 32(27): p. 6351-61. 2011;32(27):6351-61. 3. Sizeland, K.H., et al., Collagen Fibril Response to Strain in Scaffolds from Ovine Forestomach for Tissue Engineering. ACS Biomater. Sci. Eng., 2017. 3(10): p. 2550–2558. 4. Dempsey, S.G., et al., Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix. J Proteome Res, 2019. 18(4): p. 1657-1668. 5. Greaves, N.S., et al., Acute cutaneous wounds treated with human decellularised dermis show enhanced angiogenesis during healing. PLoS One, 2015. 10(1): p. e0113209. 6. Data on file.
Chaffin, A. E. and G. Bohn (2019). Clinical Evaluation of an Extracellular Matrix Surgical Graft for Reconstructive Surgery over Exposed Bone or Tendon. Symposium for Advanced Wound Care – Fall, Las Vegas, NV.
Chaffin, A. E., A. M. Aballay, G. A. Bohn, P. M. Glat, M. N. Desvigne and B. C. May (2019). Multi-Centre Clinical Evaluation of a Cell Conductive Extracellular Matrix Surgical Mesh in Plastics and Reconstructive Surgery – A Case Series. SESPRS 62nd Annual Scientific Meeting, Naples, Florida.
Chaffin, A. E., A. M. Aballay, G. A. Bohn, P. M. Glat, M. N. Desvigne and B. C. H. May (2019). Multi-Centre Clinical Evaluation of a Cell Conductive Extracellular Matrix Surgical Mesh in Plastics and Reconstructive Surgery – A Case Series. 41st Annual Boswick Burn & Wound Symposium, Wailea Beach, Maui, HI.
Overbeck, N., G. M. Nagvajara, S. Ferzoco, B. C. H. May, A. Beierschmitt and S. Qi (2020). “In-vivo evaluation of a reinforced ovine biologic: a comparative study to available hernia mesh repair materials.” Hernia |full-text available|
Dempsey, S. G., C. H. Miller, R. C. Hill, K. C. Hansen and B. C. H. May (2019). “Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix.” J Proteome Res 18(4): 1657-1668.|full-text available|
Karnik, T., S. G. Dempsey, M. J. Jerram, A. Nagarajan, R. Rajam, B. C. H. May and C. H. Miller (2019). “Ionic silver functionalized ovine forestomach matrix – a non-cytotoxic antimicrobial biomaterial for tissue regeneration applications.” Biomater Res 23: 6. |full-text available|
Frost, S. J., D. Mawad, R. Wuhrer, S. Myers and A. Lauto (2018). “Semitransparent bandages based on chitosan and extracellular matrix for photochemical tissue bonding.” Biomed Eng Online 17(1): 7. |full-text available|
Sizeland, K. H., H. C. Wells, S. J. R. Kelly, K. E. Nesdale, B. C. H. May, S. G. Dempsey, C. H. Miller, N. Kirby, A. Hawley, S. Mudie, T. Ryan, D. Cookson and R. G. Haverkamp (2017). “Collagen Fibril Response to Strain in Scaffolds from Ovine Forestomach for Tissue Engineering.” ACS Biomater. Sci. Eng. 3(10): 2550–2558. |abstract only|
Street, M., A. Thambyah, M. Dray, S. Amirapu, D. Tuari, K. E. Callon, J. D. McIntosh, K. Burkert, P. R. Dunbar, B. Coleman, J. Cornish and D. S. Musson (2015). “Augmentation with an ovine forestomach matrix scaffold improves histological outcomes of rotator cuff repair in a rat model.” J Orthop Surg Res 10: 165. |abstract only|
Negron, L., S. Lun and B. C. H. May (2014). “Ovine forestomach matrix biomaterial is a broad spectrum inhibitor of matrix metalloproteinases and neutrophil elastase.” Int Wound J 11(4): 392-397. |abstract only|
Irvine, S. M., J. Cayzer, E. M. Todd, S. Lun, E. W. Floden, L. Negron, J. N. Fisher, S. G. Dempsey, A. Alexander, M. C. Hill, A. O’Rouke, S. P. Cunningham, C. Knight, P. F. Davis, B. R. Ward and B. C. H. May (2011). “Quantification of in vitro and in vivo angiogenesis stimulated by ovine forestomach matrix biomaterial.” Biomaterials 32(27): 6351-6361. |abstract only|
Floden, E. W., S. F. Malak, M. M. Basil-Jones, L. Negron, J. N. Fisher, S. Lun, S. G. Dempsey, R. G. Haverkamp, B. R. Ward and B. C. May (2010). “Biophysical characterization of ovine forestomach extracellular matrix biomaterials.” J Biomed Mater Res B Appl Biomater 96(1): 67-75. |abstract only|
Lun, S., S. M. Irvine, K. D. Johnson, N. J. Fisher, E. W. Floden, L. Negron, S. G. Dempsey, R. J. McLaughlin, M. Vasudevamurthy, B. R. Ward and B. C. H. May (2010). “A functional extracellular matrix biomaterial derived from ovine forestomach.” Biomaterials 31(16): 4517-4529. |abstract only|
Dr Abigail Chaffin, MD, Associate Professor of Surgery, Division of Plastic Surgery, Tulane University discusses use of the Myriad™ Soft Tissue Matrix in a complex forearm reconstruction, including z-plasty.
Dr Abby Chaffin, MD, Associate Professor of Surgery, Division of Plastic Surgery, Tulane University discusses use of the Myriad™ Soft Tissue Matrix for reconstruction in Hidradenitis Suppurativa.