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Overview

Endoform™ Antimicrobial Restorative Bioscaffold and Endoform™ Natural Restorative Bioscaffold are unique extracellular matrix (ECM) products for the management of acute and chronic wounds. Endoform™ products support all phases of wound healing and are appropriate for use early in wound management to restore protease balance and advance healing to the proliferative phase.(1)

Endoform™ products:

  • Provide a natural porous ECM bioscaffold for rapid cell infiltration(2)
  • Contains more than 150 ECM proteins known to be important in wound healing(3)
  • Contain residual vascular channels to support the establishment of new vasculature(4)
  • Can indicate the presence or absence of proteases and help restore protease balance and guide re-application(5)
  • Can be used by any wound care provider from day 1(1)

Endoform™ Antimicrobial Restorative Bioscaffold contains 0.3% ionic silver, appropriate for use in early acute and chronic wound management where there is an elevated risk of infection.

  • Provides broad spectrum antimicrobial activity for up to 7 days*(6)
  • Prevents biofilm formation(6)
  • Is non-cytotoxic to dermal cells(6)

*Endoform™ Antimicrobial contains 0.3% ionic silver to protect the dressing from microbial colonization

Ionic silver have been included in the Endoform™ Antimicrobial to protect the device from microbial contamination. Reduction in colonization or microbial growth on the device has not been shown to correlate with a reduction in infections in patients. Clinical studies to evaluate reduction in infection have not been performed.

1. G. A. Bohn, G. S. Schultz, B. A. Liden, M. N. Desvigne, E. J. Lullove, I. Zilberman, M. B. Regan, M. Ostler, K. Edwards, G. M. Arvanitis and J. F. Hartman: Proactive and Early Aggressive Wound Management: A Shift in Strategy Developed by a Consensus Panel Examining the Current Science, Prevention, and Management of Acute and Chronic Wounds. Wounds, 29(11), S37-S42 (2017). 2. S. Lun, S. M. Irvine, K. D. Johnson, N. J. Fisher, E. W. Floden, L. Negron, S. G. Dempsey, R. J. McLaughlin, M. Vasudevamurthy, B. R. Ward and B. C. May: A functional extracellular matrix biomaterial derived from ovine forestomach. Biomaterials, 31(16), 4517-29 (2010) doi:10.1016/j.biomaterials.2010.02.025. 3. S. G. Dempsey, C. H. Miller, R. C. Hill, K. C. Hansen and B. C. H. May: Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix. J Proteome Res, 18(4), 1657-1668 (2019) doi:10.1021/acs.jproteome.8b00908. 4. Data on file. 5. G. A. Bohn: Endoform: A Simple Tool to Assess Wound Proteases. Wound Management and Prevention, 65(3), 18-20 (2019). 6. T. Karnik, S. G. Dempsey, M. J. Jerram, A. Nagarajan, R. Rajam, B. C. H. May and C. H. Miller: Ionic silver functionalized ovine forestomach matrix – a non-cytotoxic antimicrobial biomaterial for tissue regeneration applications. Biomater Res, 23, 6 (2019) doi:10.1186/s40824-019-0155-0

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