Myriad™ devices contain the natural porous structure of AROA ECM™, engineered with interstitial perforations to enable cell infiltration to facilitate rapid healing.
Fast absorption of blood & cells accelerates host cell infiltration
The rapid absorption of blood and blood components forms a reservoir of biologically important cells and cell components to help kick-start the tissue repair process.(1-4) Fibroblast, endothelial and immune cells infiltrate the entire matrix, build new tissue and over time Myriad™ is completely remodeled by the patient’s own tissue.(3, 4)
Delivers biology known to be important in healing
Myriad™ retains the authentic structure and complexity of natural tissue ECM and provides biological cues to aid the repair process.(5) Myriad™ contains more than 150 ECM proteins, including collagen and other secondary molecules that exist in tissue and aid the healing process.(6)
Contains residual vascular channels
Angioconduction is the structural effect of vascular channels on endothelial cells to support blood vessel development. Myriad™ promotes angioconduction via the residual vascular channels within the Aroa ECM™ source biomaterial, helping to facilitate the rapid establishment of a dense capillary network.(7, 8)
1. G. A. Bohn and A. E. Chaffin: Extracellular matrix graft for reconstruction over exposed structures: a pilot case series. J Wound Care, 29(12), 742-749 (2020) doi:10.12968/jowc.2020.29.12.742 2. A. E. Chaffin and M. C. Buckley: Extracellular matrix graft for the surgical management of Hurley stage III hidradenitis suppurativa: a pilot case series. J Wound Care, 29(11), 624-630 (2020) doi:10.12968/jowc.2020.29.11.624 3. S. M. Irvine, J. Cayzer, E. M. Todd, S. Lun, E. W. Floden, L. Negron, J. N. Fisher, S. G. Dempsey, A. Alexander, M. C. Hill, A. O’Rouke, S. P. Gunningham, C. Knight, P. F. Davis, B. R. Ward and B. C. H. May: Quantification of in vitro and in vivo angiogenesis stimulated by ovine forestomach matrix biomaterial. Biomaterials, 32(27), 6351-61 (2011) doi:l10.1016/j.biomaterials.2011.05.040 4. N. Overbeck, G. M. Nagvajara, S. Ferzoco, B. C. H. May, A. Beierschmitt and S. Qi: In-vivo evaluation of a reinforced ovine biologic: a comparative study to available hernia mesh repair materials. Hernia, 10.1007/s10029-019-02119-z (2020) 5. S. Lun, S. M. Irvine, K. D. Johnson, N. J. Fisher, E. W. Floden, L. Negron, S. G. Dempsey, R. J. McLaughlin, M. Vasudevamurthy, B. R. Ward and B. C. May: A functional extracellular matrix biomaterial derived from ovine forestomach. Biomaterials, 31(16), 4517-29 (2010) doi:10.1016/j.biomaterials.2010.02.025 6. S. G. Dempsey, C. H. Miller, R. C. Hill, K. C. Hansen and B. C. H. May: Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix. J Proteome Res, 18(4), 1657-1668 (2019) doi:10.1021/acs.jproteome.8b00908 7. Data on file 8. N. S. Greaves, S. A. Lqbal, J. Morris, B. Benatar, T. Alonso-Rasgado, M. Baguneid and A. Bayat: Acute cutaneous wounds treated with human decellularised dermis show enhanced angiogenesis during healing. PLoS One, 10(1), e0113209 (2015) doi:10.1371/journal.pone.0113209