Endoform® is a proprietary extracellular matrix (ECM) biomaterial containing a rich and complex mix of important biological molecules, including structural (collagens I, III, IV & elastin) and adhesive proteins (fibronectin and laminin), glycosaminoglycans (heparin sulphate and hyaluronic acid) and growth factors (FGF2 & TGFß).
Cells and the surrounding ECM constantly interact to modulate tissue physiology. ECM components play important roles in regulating tissue growth and maintenance and orchestrating the process of tissue regeneration. The delicate micro-architecture influences the way cells attach, migrate, grow and differentiate. Structural proteins such a collagens and elastin support cells as well as binding and releasing growth factors, cytokines, peptide fragments, proteoglycans and glycosaminoglycans. Collagen and elastin also act as substrates for matrix metalloproteinases (MMP’s) and elastase.